The Keller Laboratory at cc-TDI: 02/01/2014

Sunday, February 23, 2014

Ken's paper highlighted in Nature Reviews Cancer!

Please see the February 2014 Nature Reviews Cancer for a Research Highlight of Ken's paper that appeared last month in PLoS Genetics. The highlight written by written by NRC chief editor, Nicola McCarthy, is entitled "Flexibility could be important".

Saturday, February 22, 2014

Our thanks to the Trey Foote Foundation

We are grateful to the family, board and community supporters of the Trey Foote Foundation for the fundraiser and osteosarcoma awareness event last night at the Fort Vancouver Reserve. This remarkable evening was organized over 9 months by the students of the International Air and Hospitality Academy (special thanks to Tim Kossow). This event was both seamless and fun, and we can't thank enough the generous attendees to making the night such a success.

for the Doenbecher - Trey Foote Foundation blog, click here.

Wednesday, February 19, 2014

our thanks to the Kyla McCullough GIft Fund!

We are grateful to the Kyla McCullough Gift Fund who today presented a check for the purchase of a
multiwell electroporator instrument. This instrument allows our researchers to perform highly efficient genetic studies of primary tumor cells and cell lines -- a completely new set of experiments we could only do with this special instrument! It was great to spend time today with Bret, Brettie, Jen and Matt. Kyla has a daily presence in our research.

Friday, February 14, 2014

Childhood cancer foundations partner towards a clinical trial with OHSU-Doernbecher

press release adapted from The Doernbecher Connection (Winter 2014, Issue 3)

Beech Grove, KY; Miami, Florida; Portland, OR

Two children who found worldwide acclaim through their inspirational battles with childhood cancer continue to make an impact. The Thumbs Up for Lane Goodwin Childhood Cancer Foundation and the Live Like Bella™ Foundation for Childhood Cancer have announced the joint funding of the $180,000 “Lane-Bella Project.” The Lane-Bella Project, under the direction of Charles Keller, M.D., an associate professor of pediatrics at Oregon Health and Science University Doernbecher Children’s Hospital and a member of the OHSU Knight Cancer Institute, is a new set of studies to prepare for a clinical trial focusing on Rhabdomyosarcoma, the aggressive childhood cancer that took the lives of both Lane Goodwin, age 13, and Bella Rodriguez-‐Torres, age 10. The study will focus on finding an antibody to stop the growth of childhood muscle cancers. Once preclinical studies are complete, children around the world might benefit from these new innovations as early as 2015. The trial is the largest project funded by the two foundations, with each contributing $90,000, and includes the $20,000 donation that the MLB National League Rookie of the Year, Marlins Pitcher Jose Fernandez, directed to the Live Like Bella™ after receiving the honor.

“I want to help children with cancer. I’m proud to support life changing research to help find a cure.” ‐Jose Fernandez

Gifts designated for the Lane-Bella Project will also be applied to the historic Knight Cancer Challenge. Nike co-founder Phil Knight and his wife, Penny, will match OHSU’s fundraising efforts if it meets its $500 million fundraising goal by the end of 2015, totaling $1 billion to advance the Knight Cancer Institute’s vision to end cancer as we know it. To learn more, visit ohsu.edu/knightcancerchallenge.

The Thumbs Up for Lane Goodwin Childhood Cancer Foundation works in memory of its founder, Lane Goodwin. It funds cuttng edge research to find a cause and a cure for childhood cancers, empowers families to advocate on behalf of their children, and provides financial assistance to families through the “Changing Lanes” program. For more information, visit www.ThumbsUpForLane.org

The Live Like Bella™ Foundation was founded in memory of Bella Rodriguez-‐Torres. It funds innovatve pediatric cancer research, provides recreatonal support for families with children in treatment and assists families who have lost a child to cancer.
For more informaton, visit
www.LiveLikeBella.org.
#ThumbsUpForLane
#LiveLikeBella
#LaneBellaProject
#NoChildFightsAlone

Friday, February 7, 2014

ALSF REACH grant highlighted in Portland Business Journal

Megan's project, sponsored by the Alex's Lemonade Stand Foundation, was highlighted today by Elizabeth Hayes in the Portland Business Journal. For project updates, click here.

You Can Participate in our Novel Therapeutics Studies !

One would like to think that tangibly better treatments for rhabdomyosarcoma, medulloblastoma and other childhood cancers can be found in a matter of years, instead of tens of years. Finding new treatments starts with research, perhaps even a new research approach to identifying effective new treatments. The Children's Cancer Therapy Development Institute focuses on finding molecules in childhood cancers that can be directly turned off or on by drugs so that the tumor stops growing. Behind our novel approach is the use of genetically-engineered mice. Our Pediatric Preclinical Testing Initiative uses mice modified from before birth so that at a certain age, and in a certain tissue, the same mutations found in a child’s cancer are activated in the mouse. These special mouse models of childhood cancer can be used to test a treatment to see whether the tumor growth and spread (metastasis) can be reversed. The specific aspect of these mice having normal immune systems is a real plus, too, because white blood cells play an important role in how tumors evolve and respond to therapy.

Our program is designed around community participation. Through the Children's Cancer Therapy Development Institute, you can contribute directly to this grass-roots initiative. Donations through small gifts or grants will assist in studying compounds that may be effective in treating such childhood cancers as alveolar rhabdomyosarcoma, embryonal rhabdomyosarcoma, or medulloblastoma (the alveolar rhabdomyosarcoma model was featured by Dr. Keller's long time collaborator and former mentor, 2007 Nobel laureate Mario Capecchi, in his Nobel Prize lecture {see 16 minutes onward}.)

For additional information regarding supporting this program please contact Charles Keller at charles@cc-tdi.org. Results obtained through these studies will be shared with the National Cancer Institute’s Cancer Therapy Evaluation Program, as well as the Children’s Oncology Group, which designs clinical trials for childhood cancer.