Friday, October 31, 2014

AACR Pediatric Cancer Think-Tank

This week the AACR held a think-tank in Philadelphia on the critical issues in childhood cancer research and care delivery.   In attendance were 43 invitees from universities, pharmaceutical companies and patient advocacy groups.  Topics included prevention (yes, prevention!), improved care for hereditable cancer predispositions, making drugs available for children with cancer, and the promise of genomics in delivering personalized cancer care.  Charles presented on the topic that not only mutation but also cell of origin strongy influences response to treatment - and the types of epigenetic therapies that can be given.  

Monday, October 20, 2014

exciting news

How much is a tumor like a wound?  Will tumor cells interact with the body's normal muscle stem cells, co-opting them for advantage to the tumor?  Can IL-4 Receptor antibodies block this process? These are the questions in our NIH R01 grant application that was scored this week in the top 4% of grants for that review cycle (usually, the top 9% of grants are funded).  We're very excited about this grant, and the probable 5 years of funding to pursue these question that we think will benefit patients with rhabdomyosarcoma in a tangible way.  Kudos to Megan, who took strong work by Imran, Tohru and GH to the next level and made this project possible.

 

Tuesday, October 7, 2014

SARC SPORE meeting

We presented our research project in collaboration with Dr. David Langenau (MGH) at today's SARC clinical trial consortium SPORE meeting - we are grateful for this 2 year pilot project funding.  Differentiation as a therapy for rhabdomyosarcoma? possibly! 

Friday, October 3, 2014

upcoming lab participation & talks

AACR Pediatric Cancer Think Tank (October 2014)
Pablove Foundation Pediatric Soft Tissue Sarcoma Symposium Think Tank (November 2014)
AACR Recent Advances Sessions (April 2015)
AACR Special Conference on The Basic Science of Sarcomas (November 2015)

Sunday, September 21, 2014

Children's Oncology Group Fall Meeting

This meeting was productive.  Our lab presented at the Soft Tissue Sarcoma Chemotherapy Breakout session on "Three novel target-therapy pairs for potential clinical trials within 18 months?", as well as at the CNS session on "Ad Hoc Preclinical Consortia to Support Trial Design".  Both presentations bridged scientific/drug discovery and the potential initiation of clinical trials.    

Tuesday, September 16, 2014

Cold Spring Harbor Laboratory

We are grateful to collaborator Chris Vakoc for the opportunity to present the lecture, "Rhabdomyosarcoma:  Developmental Origins & Therapeutic Opportunities" as the prelude to a collaboration made possible by generous rhabdomyosarcoma patient advocates in this community.  

Monday, September 1, 2014

Save the Date: Rhabdomyosarcoma & Soft Tissue Sarcoma Conference

The Pablove Foundation is hosting a scientific conference on rhabdomyosarcoma & soft tissue sarcoma November 6-8, 2014 in Los Angeles.  This is a by-invitation meeting for clinician-scientists and researchers from the US and abroad; however, the symposium on Saturday November 8 will be open to the public.  Registration information will likely be available late Summer/early Fall through the Pablove Foundation website.  
  
update:  the website is now open for registration.