See also our related blog for the Pediatric Preclinical Testing Initiative.

Tuesday, November 16, 2004

Alveolar Rhabdomyosarcoma mouse model revealed

Charles Keller, Ben Arenkiel, Nabeel El-Bardeesy, Cheryl Coffin, Ronald DePinho, Mario Capecchi.  “Alveolar Rhabdomyosarcomas in Conditional Pax3:Fkhr Mice: Cooperativity of Ink4a/ARF and Trp53 Loss of Function,” Genes & Development, 18(21) 2614-26, November 2004 [PubMed UID 15489287]

Monday, November 15, 2004

Pax3:Fkhr biology in Embryogenesis

Charles Keller, Mark S. Hansen, Cheryl Coffin, Mario Capecchi.  “Pax3:Fkhr interferes with Embryonic Pax3 and Pax7 Function: Implications for Alveolar Rhabdomyosarcoma Cell of Origin,” Genes & Development, 18(21) 2608-13, November 2004 [PubMed UID 15520281]

  Comment in: Nicola McCarthy. Divining forks for developing tumours.  Nature Reviews | Cancer.  2004; Volume 4:835

Thursday, October 14, 2004

Muscling in on a Deadly Cancer

This was an article pusblished at the University of Utah News and Public Relations. In a pair of new studies, University of Utah scientists took early but significant steps to fight a particularly deadly childhood muscle cancer by identifying some of the genetic events that cause the disease and then engineering mice that develop the tumors. The genetic events might be targets for new drugs that could be tested on the mice. Click here to read more.

Lee Siegel. Press Release 10/14/2004.

Tuesday, June 1, 2004

GST Polymorphism relating to Childhood Cancer Risk

Phillip Barnette, Rebecca Scholl, Mary Blandford, Linda Ballard, Alexander Tsodikov, Jalene Magee, Susana Williams, Margaret Robertson, Francis Ali-Osman, Richard Lemons, Charles Keller. “High Throughput Detection of Glutathione S-Transferase Polymorphic Alleles in a Pediatric Cancer Population,” Cancer Epidemiology, Biomarkers, and Prevention 2004; 13:304-313 [PubMed UID 14973099]

Sunday, February 15, 2004

Notes on the clinical care of Myofibrosarcoma

Charles Keller, Callie Gibbs, Steven Kelly, Jeffrey Haller, Keith White, Cheryl Coffin, Richard Lemons. “Low Grade Myofibrosarcoma of the Head and Neck:  Importance of Early Referral and Surgical Therapy,” Journal of Pediatric Hematology-Oncology 2004; 26:119-120 [PubMed UID 14767203]