See also our related blog for the Pediatric Preclinical Testing Initiative.

Monday, December 5, 2011

now in print: Bortezomib acts through NOXA in Medulloblastoma

Congratulations again to lab alumni Sachiko and Monika for the publication this month in the Journal of Neuro-Oncology of our study, "Bortezomib stabilizes NOXA and triggers ROS-associated apoptosis in medulloblastoma".  Co-authors include lab alumni Tohru and Laura.  This was a very exciting study funded by the National Brain Tumor Society and the Hyundai Motor Corporation Hope on Wheels Program (precursor studies were funded by St Baldrick's Foundation).  These results have piqued our interest in similar compounds such as Carfilzomib for pediatric medulloblastoma.