The Keller Laboratory at cc-TDI: 03/01/2010

Wednesday, March 31, 2010

Our Laboratory is Moving to OHSU, Portland !

I'm excited to announce that our laboratory is moving to the Oregon Health & Science University where my team and I will be building and leading a Pediatric Cancer Biology program as well as a robust Preclinical Testing Program for childhood cancers. Whether to move a laboratory requires careful consideration, as described by Joe Simone in his 'Maxims'. Some key aspects in pursuing this opportunity for our lab are:

- an existing COG Pediatric Oncology Phase I program, so that we can more easily move new treatments from the laboratory bench to the clinic,

- Strong leadership in the Department of Pediatrics by Chairman and pediatric oncologist, Dr. Stacy Nicholson,

- Clinical trials expertise including Pediatric Hematology Oncology division chief, Dr. Linda Stork, and Phase I program PI, Dr. Suman Malempati (who currently conducts a COG clinical trial of an Igfr-1 inhibitor for rhabdomyosarcoma),

- An exceptional stem cell biology community with the Oregon Stem Cell Center to complement our interest in muscle and tumor stem cells,

- Field-leading expertise in gene therapy, including the research of Pape' Family Pediatric Research Institute Director, Dr. Markus Grompe, and fellow pediatric oncologist faculty member, Peter Kurre,

- A tradition of excellence in Neuroscience, complementing our interests in medulloblastoma, through the Vollum Institute led by Dr. Richard Goodman,

- a strong Division of Biomedical Engineering to enhance our multi-disciplinary approach to cancer research,

- opportunity to partner with the community in growing the pediatric cancer biology program faculty through collaboration with The Doernbecher Children's Hospital Foundation,

and importantly,

- the opportunity to collaborate with 2009 Lasker-Debakey Prize awardee, Dr. Brian Druker. Brian and colleagues pioneered the use of Imatinib (Gleevec, or STI571) as a targeted molecular therapeutic for Chronic Myelogenous Leukemia (CML). This precedent of finding a non-chemotherapy treatment for CML is one that we would very much like to repeat for childhood cancers. Such an approach would make a lot of sense, because growth factor receptors known to be active in many childhood cancers belong to the classes of kinases for which many new drugs are being developed for adult cancer. We have already had very productive collaborations with our colleagues Drs. Jason Glover, Jeff Tyner and Mark Loriaux in the Druker laboratory that will lead to co-authored studies this Spring.

We look forward to being a part of the OHSU community, and forging new ground in the discovery of novel and more effective treatments for childhood cancer.

Charles

"Start by doing what is necessary, then do what is possible, and suddenly you are doing the impossible", St. Francis of Assisi

[ above right: Mt Hood and Downtown Portland. photo credit, USGS ]

Friday, March 26, 2010

Spring COG meeting in Los Angeles

The Children's Oncology Group Spring 2010 meeting was held in Los Angeles March 24 - 26, with our participation being in the Soft Tissue Sarcoma, Preclinical Testing and CNS (brain tumor) sessions. Research by Jinu and Anu was very well received at the Tuesday sarcoma session in Charles' presentation of, "Preclinical Rhabdomyosarcoma Studies in Genetically-Engineered Mice". These meetings are fabulous for establishing new treatment paradigms that bridge basic science and clinical trials.

Molecularly targeted therapies are generating a lot of excitement.

Friday, March 12, 2010

It pays to have a sense of humor

Recently Laura went to a conference for mouse colony management and came back with some souvenirs. Oddly, they seem to have a life of their own. It's certainly nice to have light moments every once in a while.

Congratulations to Melinda & Corrine!

Congratulations to alumni graduate students, Melinda Garcia and Corrine Chua for their nominations today for the 2010 Armand J. Guarino Award for Academic Excellence in Master of Science Studies! Corrine and Melinda both completed their Masters degree from our laboratory in December 2009.

Wednesday, March 10, 2010

with thanks to Michelle

Just a short note of appreciation for our tireless colleague, Michelle Brady, the technical director of our GCCRI Histology Facility. Michelle provides fantastic support to our laboratory's research, often on short notice, and always with kindness and grace. We are grateful to have Michelle as a colleague.

Monday, March 1, 2010

National Center for Integrative Biological Computing

Congratulations to our colleagues at the Scientific Imaging and Computing Institute at the University of Utah on their very well prepared site visit for the National Center for Integrative Biological Computing. Our proposed collaborative project for this NIH P41 grant uses shape analysis to evaluate disease progression in medulloblastoma. This is a truly unique team of gifted computer scientists, and it is a privilege to be able to work together.

You Can Participate in our Novel Therapeutics Studies !

One would like to think that tangibly better treatments for rhabdomyosarcoma, medulloblastoma and other childhood cancers can be found in a matter of years, instead of tens of years. Finding new treatments starts with research, perhaps even a new research approach to identifying effective new treatments. The Children's Cancer Therapy Development Institute focuses on finding molecules in childhood cancers that can be directly turned off or on by drugs so that the tumor stops growing. Behind our novel approach is the use of genetically-engineered mice. Our Pediatric Preclinical Testing Initiative uses mice modified from before birth so that at a certain age, and in a certain tissue, the same mutations found in a child’s cancer are activated in the mouse. These special mouse models of childhood cancer can be used to test a treatment to see whether the tumor growth and spread (metastasis) can be reversed. The specific aspect of these mice having normal immune systems is a real plus, too, because white blood cells play an important role in how tumors evolve and respond to therapy.

Our program is designed around community participation. Through the Children's Cancer Therapy Development Institute, you can contribute directly to this grass-roots initiative. Donations through small gifts or grants will assist in studying compounds that may be effective in treating such childhood cancers as alveolar rhabdomyosarcoma, embryonal rhabdomyosarcoma, or medulloblastoma (the alveolar rhabdomyosarcoma model was featured by Dr. Keller's long time collaborator and former mentor, 2007 Nobel laureate Mario Capecchi, in his Nobel Prize lecture {see 16 minutes onward}.)

For additional information regarding supporting this program please contact Charles Keller at charles@cc-tdi.org. Results obtained through these studies will be shared with the National Cancer Institute’s Cancer Therapy Evaluation Program, as well as the Children’s Oncology Group, which designs clinical trials for childhood cancer.