Open Science Forum: Target Discovery in Rhabdomyosarcoma

Would members of the community be interested in sponsoring an experiment to launch drug discovery in rhabdomyosarcoma?  We are experienced in building drug screens from our leadership of the international dipg preclinical consortium and now want to build the resources to do the same thing for rhabdomyosarcoma.  We need $16,000 to build the rhabdomyosarcoma-specific 60 drug screen.  Thereafter, screening each new tumor culture would cost approximately $600. 

In parallel, we have an unusual set of other compounds which our lab members call, "Strange Brew."  There's no other way to explain this set of compounds, which draw upon every unusual observation of cancer and muscle biology since the early 1900's.  This higher risk screen is a $21,000 project... we could really use a sponsor for this second project as well.

Plates from both screens would not only be used by our lab, but also distributed to rhabdomyosarcoma research labs in the U.S. and internationally.  We have a good feeling about this.

Rhabdomyosarcoma Lab-ome

We've been asked on occasion what other labs do rhabdomyosarcoma research.  Below is a preliminary list (in no specific order)... we realize many are left off accidentally, but we will update this blog entry regularly to add more:

keller lab,   http://kellerlabblog.blogspot.com/ 

langneau lab,   http://langenaulab.com/ 

guttridge lab,   http://digitalunion.osu.edu/r2/summer09/hill/

barr lab,   http://ccr.cancer.gov/staff/staff.asp?profileid=18438

houghton lab (PPTP),   http://pptp.nchresearch.org/

rudnicki lab,   http://www.rudnickilab.ca/

schaefer lab,   http://www.cnz.uzh.ch/Research/RG4/Schafer.html

khan lab, http://ccr.cancer.gov/staff/staff.asp?profileid=5584
shipley lab,   http://www.icr.ac.uk/research/team_leaders/index.shtml

zammit lab,  http://www.kcl.ac.uk/biohealth/research/divisions/randall/research/sections/signalling/zammit/index.aspx

hollenbach lab, https://www.medschool.lsuhsc.edu/genetics/faculty_detail.aspx?name=hollenbach_andrew

mal lab, http://www.roswellpark.edu/asoke-mal

tapscott lab,   http://labs.fhcrc.org/tapscott/

ladanyi lab,   http://www.mskcc.org/research/lab/marc-ladanyi

helman lab,   http://ccr.cancer.gov/staff/staff.asp?profileid=5582

malkin lab,   http://www.sickkids.ca/AboutSickKids/Directory/People/M/David-Malkin-staff-profile.html

linardic lab,   http://pediatrics.duke.edu/faculty/details/0012491

triche lab,   http://www.chla.org/site/c.ipINKTOAJsG/b.8060567/k.4964/Timothy_J_Triche_MD_PhD_Laboratory__Ewings_Sarcoma__Pediatric_Cancer_Research.htm#.UoUrH8LTnuo

fulda lab, http://www.uct-frankfurt.de/content/forschung/e4699/e4665/e4672/index_ger.html

hosoi lab, http://www.kpu-m.ac.jp/doc/english/classes/medical/69.html
gauthier lab, http://www.crbm.cnrs.fr/spip.php?rubrique94&lang=en
galindo lab,   http://www.galindo-lab.org/Overview.html

davie lab,   http://biochem.siu.edu/faculty/Davie.html

chandler lab,   http://chandlerlab.nchresearch.org/

simone hettmer* lab,   tba

jonathan fletcher lab,   tba

amy wagers lab,   tba

rosella rota lab,   tba

alessandro fanzani lab,   tba

* rising star

a good cause

Please see this dipg-related website regarding the work of a 2012 Nanocourse parent, http://www.artforcharlie.com/what.htm.  In their shop are some very nice art cards that may be of interest.  Charles

Rally Foundation 'Legacy Gift' Project

Matthew presented the Rally Foundation for Childhood Cancer Research's Legacy Gift project via a booth at the Children's Oncology Group meeting this week in Dallas, Texas.  This project's goal is to developing tissue resources for tumor cell culture and patient-derived xenografts of rare childhood cancers.  Autopsy-derived samples ("legacy gifts") are a major emphasis of this project... with a rationale that the most resistant tumor to develop better treatments. 
 
Please see also the Rally Foundation parent interview at

https://vimeo.com/76616638.  Have some tissues ready.  

 

Patrick M. Callahan Memorial Fund

We are grateful to the Patrick M. Callahan Memorial Fund for their generous 2013 gift, which makes possible pilot studies of new research for the childhood muscle cancer, rhabdomyosarcoma.  The community of supporters of the Patrick M. Callahan Memorial Fund, and Patrick's mother Joann, are valued partners in the mission to make rhabdomyosarcoma a uniformly survivable condition.  

Molly's Story (Consano Crowdfunding Project)

See the Consano story by Cathy Marshall (KGW, NBC Portland Channel 8) at http://www.kgw.com/home/breast-cancer-mom-225379922.htm. 
  
To donate and be a contributing partner in our rhabdomyosarcoma research project, click https://www.consano.org/projects/21-halting-tumor-cells-from-spreading-by-blocking-hostile-mergers.  

Northwest Sarcoma Foundation 'DragonSlayer' Event

A picture of our team at the NWSF Event... thanks to Matthew for organizing our team!